The Uses of Clindamycin Phosphate Topical Lotion. Clindamycin Phosphate topical lotion was developed to treat moderate to severe cases of acne, when other, less aggressive, acne treatments are not enough. Topical clindamycin comes in a variety of forms, like lotions, gels, foams, medicated pads (called pledgets), and toner-like solutions. What form you'll use depends on the brand medication prescribed and what your dermatologist thinks is most appropriate for you. INDICATIONS. Clindamycin Phosphate Topical Solution, USP 1% is indicated in the treatment of acne vulgaris. In view of the potential for diarrhea, bloody diarrhea and pseudomembranous colitis, the physician should consider whether other agents are more appropriate. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except. Clindamycin Phosphate Topical Solution and Clindamycin Phosphate Lotion (Clindamycin Phosphate Topical Suspension USP, 1%) contain clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per milliliter. Après application cutanée de phosphate de clindamycine, la clindamycine est détectée dans des échantillons de comédons à des teneurs suffisantes pour être active à l'encontre de la plupart des souches de propionibacterium (Propionibacterium acnes). Clindamycin phosphate Clindamycin is a semisynthetic derivative of lincomycin , a natural antibiotic produced by the actinobacterium Streptomyces lincolnensis. It is obtained by 7( S )- chloro - substitution of the 7( R )- hydroxyl group of lincomycin. How to use Clindamycin Phosphate Gel. Use this medication only on the skin. Clean and dry the affected area first. Follow all directions on the product package, or use as directed by your doctor.